From Asheville, NC - approximately one hour. Take I-40 west to Exit 27 (the Great Smoky Mountains Expressway). Continue West on US 74 past Waynesville, Sylva and Dillsboro to Cherokee, Exit 74. (1 hour) From Atlanta (West side) - approximately three hours. Take I-75 north to I-575 north, which becomes Georgia route 5. At Blue Ridge, GA, turn left (west) on to Route 60 and travel 1.5 miles to Mineral Bluff, GA. Turn right on to Route "60 Spur" and travel approximately 12 miles to the junction with US 19/74. Turn right (east) and proceed on US 19/74 through Murphy, NC, Andrews, NC and the Nantahala Gorge to Cherokee (Exit 74). (2.5 Hours) From Atlanta (East side) - approximately( 2-1/2 hours). Take I-85 north to I-985, which becomes US 23, which becomes US 23/441.You1ll pass through Clayton, GA, Franklin, NC and Dillsboro, NC. Just past Dillsboro, take US 74 (the Great Smoky Mountains Expressway) west to Cherokee, Exit 74. From Charlotte - approximately three hours. Take I-85 west to US 74. Continue west on US 74 to I-26. Go north on I-26 to I-40. Take I-40 west to Exit 27 (US 74, the Great Smoky Mountains Expressway). Continue West on US 74 past Waynesville, Sylva and Dillsboro to Cherokee, Exit 74. (3 Hours) From Spartanburg and Greenville - approximately two to 2-1/2 hours. From Spartanburg, take I-26 north to I-40. Take I-40 west to Exit 27 (US 74, the Great Smoky Mountains Expressway). Continue West on US 74 past Waynesville, Sylva and Dillsboro to Cherokee, Exit 74. From Chattanooga - approximately 2-1/2 hours. Take I-75 north to US 64 (near Cleveland, TN). Drive east on US 64 (which becomes US 64/74) through Ducktown, TN and the Ocoee River Gorge into North Carolina. At Murphy, NC take US 19/74 east through Andrews, NC and the Nantahala Gorge to Cherokee (Exit 74). (2.5 Hours) From Knoxville - you have a choice of four routes. Driving time depends on route and traffic.(2-3 Hours) Via Interstate 40 - Take I-40 east into North Carolina to exit 27 (US 74, the Great Smoky Mountains Expressway). Continue West on US 74 past Waynesville, Sylva and Dillsboro to Cherokee, Exit 74. The drive from Knoxville to Cherokee is approximately two hours. Via US 129 - Take US 129 south through Alcoa and Maryville. After crossing into North Carolina, take US 28 south to US 74 (the Great Smoky Mountains Expressway). Continue east on US 74 approximately 20 miles to Cherokee. Note: the section of US 129 known as "Deal1s Gap" and "The Tail of The Dragon" is extremely curvy (318 curves in 11 miles). The drive from Knoxville to Cherokee is approximately three hours Via Pigeon Forge and the Great Smoky Mountains National Park - Take I-40 east to exit 407 and proceed south. At Sevierville, TN, take US 441 south through Pigeon Forge, Gatlinburg and the Great Smoky Mountains National Park to Cherokee, NC. Depending on traffic, the drive from Knoxville to Cherokee can be from two to three hours. Via Townsend and the Great Smoky Mountains National Park - Take US 129 south through Alcoa to Maryville. In Maryville, take US 321 east to Townsend, TN. From Townsend, take Little River Road east through the Great Smoky Mountains National Park to US 441 (at the Park Visitors Center). Take US 441 south through the park to Cherokee.